English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90120/105277 (86%)
Visitors : 8138127      Online Users : 74
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6708

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6708

    Title: Interleukin gene polymorphisms in age-related macular degeneration
    Authors: Yi-Yu Tsai;Jane-Ming Lin;Lei Wan;Hui-Ju Lin;Tsai-Chung Li;Chang-Hai Tsai;Fuu-Jen Tsai
    Date: 2008-02
    Issue Date: 2009-12-23 14:21:43 (UTC+8)
    Publisher: Asia University
    Abstract: PURPOSE. To investigate polymorphisms in a candidate gene of interleukin (IL) in unrelated Taiwan Chinese patients with late age-related macular degeneration (AMD) and control subjects without AMD.
    METHODS. In this retrospective, case-control study, 312 unrelated Taiwan Chinese patients with late AMD and 180 age- and sex-matched control subjects were enrolled. Late AMD was classified as either atrophic (dry) or neovascular (wet) according to the International ARM Epidemiologic Study. Genomic DNA was prepared from peripheral blood obtained from all patients with AMD and control subjects. Polymerase chain reactions were used to analyze 14 single-nucleotide polymorphisms (SNPs) in candidate genes of 5 ILs: IL-1β(2q14): –511 T/C; IL-6 (7p21): –572 C/G and –596 G/A; IL-8 (4q13-q21): –251 A/T, +781 C/T, +1633 T/C, and +2767 A/T; IL-10 (1q31-q32): –592 A/C, –819 C/T, and –1082 G/A; and IL-18 (11q22.2-q22.3): +105 A/C, –137 C/G, –607 A/C, and –656 T/G.
    RESULTS. In the 312 patients with late AMD, dry AMD was diagnosed in 136 and wet AMD in 176. Among the 14 SNPs in the 5 IL genes studied, only the IL-8 +781 C/T SNP was significantly associated with wet AMD (T allele: 46% in wet AMD versus 28% in the control subjects, P = 1.03 x 10–6, OR = 2.16, 95% CI = 1.58–2.94). The association analysis based on genotypes at both IL-8 +781 C/T and the CFH Y402H demonstrated that the IL-8 +781 C/T to AMD was not significant when analyzed conditional on the presence of the CFH Y402H C risk allele and vice versa. The IL-8 +781 C/T was in low linkage disequilibrium with CFH Y402H (D' = 0.02).
    CONCLUSIONS. The data suggest that Taiwan Chinese carriers of the IL-8 +781 T allele, independent of the CFH Y402H polymorphism, are at increased risk of developing wet AMD.
    Appears in Collections:[醫學暨健康學院] 期刊論文

    Files in This Item:

    File Description SizeFormat
    139.doc44KbMicrosoft Word473View/Open

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback