English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90074/105197 (86%)
Visitors : 7167402      Online Users : 43
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6727


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6727


    Title: A pilot study of neonatal screening by electrospray ionization tandem mass spectrometry in Taiwan
    Authors: Wei-De Lin;Wu,Jer-Yuarn;Lai,Chien-Chen;Tsai,Fuu-Jen;Chang-Hai Tsai
    Date: 2001-07
    Issue Date: 2009-12-23 14:21:52 (UTC+8)
    Publisher: Asia University
    Abstract: Amino acid and acylcarnitine profiling of dry blood specimens using electrospray tandem mass spectrometry (ESI/MS/MS) has been recognized as an useful tool for screening inherited metabolic defects of newborns. In this pilot study, we introduced this technology to screen 2100 newborns to establish the normal amino acid and acylcarnitine level. Based on the upper cutoff level (average+4*SD), twenty-nine samples studied were considered as abnormal. After follow-up samples and urine GC/MS analysis, only two were confirmed as true inborn errors. One was identified as hyperphenylalaninemia, and the other as isovaleric acidemia. The positive rate of true inborn metabolic error was 0.09% (2/2100), and the false positive rate 1.28% (29/2100) in this study. ESI/MS/MS is proven to be an adequate tool for inborn metabolic error screening.
    Relation: Acta Paediatrica Taiwanica 42 (4): 224-230
    Appears in Collections:[醫學暨健康學院] 期刊論文

    Files in This Item:

    File SizeFormat
    0KbUnknown120View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback