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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6743


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6743


    Title: The Proline Form of p53 Codon 72 Polymorphism is Associated with Endometriosis
    Authors: Chi-Chen Chang;Hsieh Yao-Yuan;Fuu-Jen Tsai;Chang-Hai Tsai;Horng-Der Tsai;Cheng-Chieh Lin
    Date: 2002
    Issue Date: 2009-12-23 14:21:58 (UTC+8)
    Publisher: Asia University
    Abstract: Objective: To evaluate the association between endometriosis and the p53 polymorphism.
    Design: Prospective study.
    Setting: Department of gynecology and genetics in a medical center.
    Patient(s): Women with and without endometriosis.
    Intervention(s): Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140).
    Main Outcome Measure(s): Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated.
    Result(s): The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis.
    Conclusion(s): Endometriosis is associated with p53 polymorphism. p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis.
    Relation: FERTILITY AND STERILITY 77 (1): 43-45
    Appears in Collections:[醫學暨健康學院] 期刊論文

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