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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6748


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6748


    Title: Study of AMP-activated Protein Kinase Agonists by Structure-based Drug Designing
    Authors: Yea-Huey Chang;Tin-Yun Ho;Chieh-Hsi Wu;Chien-Yu Chen;Hung-Jin Huang;Fuu-Jen Tsai;Chang-Hai Tsai;Chen, Calvin Yu-Chian
    Date: 2009-10
    Issue Date: 2009-12-23 14:22:01 (UTC+8)
    Publisher: Asia University
    Abstract: AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding site was defined corresponding to X-ray crystal structure of yeast AMPK By virtual screening the database., All the potent ligands had the H-bond interaction in the key residues, same as the control. Thus, we suggested the phenylamide derivates might be the potent AMPK agonists.
    Relation: ADVANCED MATERIALS & PROCESSES Volumes: 79-82
    Appears in Collections:[醫學暨健康學院] 期刊論文

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