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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6751


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6751


    Title: Tumor necrosis factor alpha, CYP 17, urokinase, and interleukin 10 gene polymorphisms in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis
    Authors: Chen HY;Huey-Yi Chen;Chen Wen-Chi;Chin-Moo Hsu;Fuu-Jen Tsai;Chang-Hai Tsai
    Date: 2005-09
    Issue Date: 2009-12-23 14:22:02 (UTC+8)
    Publisher: Asia University
    Abstract: Osteoporosis is a common disorder with a strong genetic component. We investigated the correlations between bone mineral density (BMD) and four gene polymorphisms (?308G>A tumor necrosis factor α (TNF-α), ?34T>C CYP 17, *141T>C urokinase, and ?627C>A interleukin 10 (IL-10) promoter), and their relationship to osteoporosis in postmenopausal women.
    Study design:
    These polymorphisms were determined using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis. BMD of the lumbar spine and proximal femur were measured using dual-energy X-ray absorptiometry.
    Results:
    The prevalence of each genotype was as follows: (1) 79.3% A/A, 16.6% A/G, and 4.1% G/G in ?308G>A TNF-α; (2) 18.9% T/T, 52.1% T/C, and 29% C/C in ?34T>C CYP 17; (3) 86.4% C/C and 13.6% C/T in *141T>C urokinase; (4) 46.2% A/A, 45% A/C, and 8.8% C/C in ?627C>A IL-10 promoter. Subjects with genotype C/C in ?627C>A IL-10 promoter had lower BMD values and a significantly greater risk for osteoporosis (OR 8.1, 95% CI 1.5–42.8) at the lumbar spine compared with subjects with genotype A/C in ?627C>A IL-10 promoter, after adjustment for potential confounders.
    Conclusion:
    The RsaI IL-10 promoter gene polymorphism is associated with reduced BMD and predisposes women to osteoporosis at the lumbar spine.
    Relation: EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY 122 (1): 73-78
    Appears in Collections:[醫學暨健康學院] 期刊論文

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