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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6755


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6755


    Title: CYP17 and tumor necrosis factor-α gene polymorphisms are associated with risk of oral cancer in Chinese patients in Taiwan
    Authors: Chen Wei Cheng;Ming-Hsui Tsai;Lei Wan;Chen Wen-Chi;Chang-Hai Tsai;Fuu-Jen Tsai
    Date: 2005-01
    Issue Date: 2009-12-23 14:22:04 (UTC+8)
    Publisher: Asia University
    Abstract: Conclusion Patients who carry the T/T homozygote of CYP17 C/T gene polymorphism may have a higher risk of developing oral cancer.
    Objective Cancer of the oral cavity is the most commonly seen malignancy in Taiwan, and its rising incidence poses a formidable challenge to oncologists. The CYP17 gene encodes P450c17alpha, an enzyme involved in the metabolism of steroid hormones. Tumor necrosis factor-α (TNF-α) is one of the cytokines produced by macrophages, and its function has been postulated to play a role in cancer formation. We investigated whether polymorphisms of CYP17 and TNF-α genes are associated with oral cancer.
    Material and methods Polymorphisms of CYP17 and TNF-α genes were detected by polymerase chain reaction-based restriction analysis in 137 patients with oral cancer and 102 normal controls.
    Results The results for the CYP17 gene revealed a significant difference between oral cancer patients and normal controls (p=0.0063), but there was no significant difference for the TNF-α gene (p=0.4753).
    Relation: ACTA OTO-LARYNGOLOGICA 125 (1): 96-99
    Appears in Collections:[醫學暨健康學院] 期刊論文

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