ASIA unversity:Item 310904400/6769
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90429/105609 (86%)
造访人次 : 10283297      在线人数 : 94
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻
    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6769


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/6769


    题名: Drug Design for AMP-Activated Protein Kinase Agonists in Silico
    作者: Chien-Yu Chen;Da-Tian Bau;Ming-Hsui Tsai;Yuan-Man Hsu;Tin-Yun Ho;Hung-Jin Huang;Yea-Huey Chang;Fuu-Jen Tsai;Chang-Hai Tsai;Chen, Calvin Yu-Chian
    日期: 2009-10
    上传时间: 2009-12-23 14:22:10 (UTC+8)
    出版者: Asia University
    摘要: AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding site was defined corresponding to X-ray crystal structure of yeast AMPK By virtual screening the database. All the potent ligands had the H-bond interaction in the key residues, same as the control. Thus, we suggested the phenylamide derivates might be the potent AMPK agonists.
    關聯: IEEE/ACM Transactions on Computational Biology and Bioinformatics
    显示于类别:[醫學暨健康學院] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    index.html0KbHTML210检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈