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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6773


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6773


    Title: Drug design for Influenza A virus subtype H1N1
    Authors: Chien-Yu Chen;Da-Tian Bau;Yea-Huey Chang;Yuan-Man Hsu;Tin-Yun Ho;Hung-Jin Huang;Fuu-Jen Tsai;Chang-Hai Tsai;Chen, Calvin Yu-Chian;Yu-An Chang
    Date: 2009-10
    Issue Date: 2009-12-23 14:22:12 (UTC+8)
    Publisher: Asia University
    Abstract: An outbreak of influenza A virus subtype H1N1, also known as swine flu, in Mexico was occurred in April 2009. To design drugs for treating this epidemic is urgency. In this study, we employed the new sequences (2009) to build the N1 simulation structure by homology modeling, which has been checked for high reliability by Verify Score and Ramachandran plot. The latest H1 homology model was employed from Chen's report. 365,602 compounds from NCI database have been screened by docking study of H1 and N1, respectively. And then, nine candidates were screened and suggested as potent dual target candidates from the docking studies. In our investigation, drug resistance was found by our molecular simulation in the new N1 modeling structure to oseltamivir. However, the mechanism is still not clear; further clinical investigations are urgently required.
    Relation: JOURNAL OF THE CHINESE INSTITUTE OF CHEMICAL ENGINEERS
    Appears in Collections:[醫學暨健康學院] 期刊論文

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