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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6776

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6776

    Title: Proliferative effects of chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent
    Authors: Kun Shan Huang;Min-Jin Lu;Yueh-Sheng Chen;Fuu-Jen Tsai;Wei-Wen Kuo;Yi-Chang Cheng;Chien-Chung Lin;Chang-Hai Tsai;Chih-Yang Huang;Jaung-Geng Lin;Hsiu-Chung Ou
    Date: 2009
    Issue Date: 2009-12-23 14:22:15 (UTC+8)
    Publisher: Asia University
    Abstract: This study evaluated the proliferative effects of chishao on RSC96, Schwann cells. A dose-dependent proliferative effect of chishao was obtained by methylthiazol tetrazolium (MTT), proliferating cell nuclear antigen (PCNA) Western blotting, and wound healing assays in Schwann cells administered with chishao (0-500 mg/ml), except at 500 mg/ml concentration. The chishao-treated cells also showed a dose-dependent activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA) and decreased plasminogen activator inhibitor-1 (PAI-1), enhanced proliferative proteins, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-signaling. Using mitogen-actvated protein kinase (MAPK)-signaling chemical inhibitors, U0126, SB203580, and SP600125, the proliferative effects of chishao on RSC cells were identified to be ERK- and JNK- signaling dependent. Based on the results, applying appropriate doses of chishao to Schwann cells would be a potential approach for enhancing neuron regeneration.
    Relation: AMERICAN JOURNAL OF CHINESE MEDICINE 37 (6): 1191-202
    Appears in Collections:[醫學暨健康學院] 期刊論文

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