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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6781


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6781


    Title: Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice
    Authors: Hsu TC;Chih-Yang Huang;Chiang SY;Lai WX;Chang-Hai Tsai;Tzang BS
    Date: 2008-06
    Issue Date: 2009-12-23 14:22:18 (UTC+8)
    Publisher: Asia University
    Abstract: Increased hepatic abnormality has been observed in patients with systemic lupus erythematosus (SLE) and contributes to the elevated apoptosis that results in severe disease activity. Since cystamine has been demonstrated to be beneficial for NZB/W F1 mice, this study investigates the effects of cystamine on various inflammatory and stress-related proteins in liver from NZB/W F1 mice. Nephelometric analyses and immunoblots were conducted to detect aspartate aminotransferase (AST), alanine aminotransferase (ALT), C-reactive protein (CRP), p53, p21, Gadd45, heat shock protein 70 (HSP70) and cyclooxygenase-2 (COX-2). AST and ALT were reduced in NZB/W F1 mice that were given cystamine and CRP, p53, p21, Gadd45, HSP70 and COX-2 proteins in the liver were reduced in NZB/W F1 mice that were treated with cystamine. Moreover, cystamine has no obvious effect on BALB/c mice. These findings suggest that cystamine reduces the inflammation in liver of NZB/W F1 mice and provide a clue in treatment of SLE with liver abnormality.
    Relation: EUROPEAN JOURNAL OF PHARMACOLOGY 579 (1-3): 382-389
    Appears in Collections:[醫學暨健康學院] 期刊論文

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