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    ASIA unversity > 醫學暨健康學院 > 期刊論文 >  Item 310904400/6784


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/6784


    Title: Japanese Encephalitis Virus Envelope Protein Mitigates TNF-α mRNA Expression in RAW264.7 Cells
    Authors: Hsu Tsai-Ching;Gao Ji-Qiang;Lu Ko-Hsiu;Chang-Hai Tsai;Chih-Yang Huang;Tzang Bor-Show
    Date: 2008-03
    Issue Date: 2009-12-23 14:22:19 (UTC+8)
    Publisher: Asia University
    Abstract: Japanese encephalitis virus (JEV) is known as an important mosquito-borne human pathogen that causes Japanese encephalitis and may lead to lethal effect. Since monocyte has been demonstrated to play transmissible role for JEV, rare study is reported to clarify the effect of JEV envelope (JEVE) protein on monocyte. This study intends to investigate the effects of JEVE protein inside monocyte. Notably, significant decreased expression of tumour necrosis factor (TNF)-α mRNA in RAW264.7 cells transfected with pEGFP-JEVE was observed as compared to those cells transfected with pEGFP. Increased p21Waf1/Cip1 protein was observed in both pEGFP and pEGFP-JEVE transfected RAW264.7 cells. However, increased p53 protein was only detected in pEGFP-transfected cells but not pEGFP-JEVE transfected cells as well as the result that no increased expression of nuclear factor-kB was observed in pEGFP-JEVE transfected cells. These experimental results indicate the effects of JEVE protein in alleviating TNF-α mRNA expression that is associated with the increased p53-independent p21Waf1/Cip1 expression and provide an explanation in the role of JEV transmission through monocyte.
    Relation: INFLAMMATION 31 (2): 133-140
    Appears in Collections:[醫學暨健康學院] 期刊論文

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