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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/7834

    Title: A New Inhibitor for Fructosamine 3-Kinase (Amadorase)
    Authors: 蔡建鈞;Henry J Tsai;Shan-Yen Chou;Frank Kappler;Michael L Schwartz;and Annette M Tobia
    Keywords: advanced glycation end products;3-deoxyglucosone;fructosamine 3-kinase;glycation;inhibitor;protein deglycation
    Date: 2006
    Issue Date: 2010-02-26
    Publisher: Asia University
    Abstract: Non-enzymatic glycation is a Maillard reaction that occurs spontaneously between glucose and proteins and results in the accumulation of advanced glycation end products (AGEs), which are believed to be one of the causes for age-related tissue damage. Fructosamine 3-kinase (FN3K) is an enzyme involved in the protein deglycation process by fructosyl phosphorylation, returning amino acid residues to their pristine state with 3-deoxyglucosone (3-DG) and inorganic phosphate as by-products. 3-DG is a very reactive electrophile that is even more potent at generating AGEs than glucose; therefore, inhibitors specific to FN3K have been suggested as a means to suppress 3-DG formation. Dyn-12 is a substrate mimicking inhibitor with an IC50 value of approximately 6 mM. We report a new hydrophobic competitive inhibitor with respect to fructolysine that has an IC50 of 1.7 mM. Drug Dev. Res. 67:448-455, 2006. ? 2006 Wiley-Liss, Inc.
    Relation: Drug Development Research 67:448-455
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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