English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90074/105197 (86%)
Visitors : 7158885      Online Users : 43
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/7834


    Title: A New Inhibitor for Fructosamine 3-Kinase (Amadorase)
    Authors: 蔡建鈞;Henry J Tsai;Shan-Yen Chou;Frank Kappler;Michael L Schwartz;and Annette M Tobia
    Keywords: advanced glycation end products;3-deoxyglucosone;fructosamine 3-kinase;glycation;inhibitor;protein deglycation
    Date: 2006
    Issue Date: 2010-02-26
    Publisher: Asia University
    Abstract: Non-enzymatic glycation is a Maillard reaction that occurs spontaneously between glucose and proteins and results in the accumulation of advanced glycation end products (AGEs), which are believed to be one of the causes for age-related tissue damage. Fructosamine 3-kinase (FN3K) is an enzyme involved in the protein deglycation process by fructosyl phosphorylation, returning amino acid residues to their pristine state with 3-deoxyglucosone (3-DG) and inorganic phosphate as by-products. 3-DG is a very reactive electrophile that is even more potent at generating AGEs than glucose; therefore, inhibitors specific to FN3K have been suggested as a means to suppress 3-DG formation. Dyn-12 is a substrate mimicking inhibitor with an IC50 value of approximately 6 mM. We report a new hydrophobic competitive inhibitor with respect to fructolysine that has an IC50 of 1.7 mM. Drug Dev. Res. 67:448-455, 2006. ? 2006 Wiley-Liss, Inc.
    Relation: Drug Development Research 67:448-455
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    0KbUnknown212View/Open
    310904400-7834 .doc30KbMicrosoft Word203View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback