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    Title: Antrodiasalmonea inhibits TNF-α-induced angiogenesis and atherogenesis in human endothelial cells through the down-regulation of NF-κB and up-regulation of Nrf2 signaling pathways
    Authors: Ya, Hsin-Ling;Yang, Hsin-Ling;張竣維;Hebron, C.Chang;Lin, Shu-Wei;Lin, Shu-Wei;K.J.Senthil;Kuma, K.J.Senthil;Li, Chun-Huei;Liao, Chun-Huei;Wang, Hui-Min;Wang, Hui-Min;Lin, Kai-Yuan;Lin, Kai-Yuan;許游章;Hseu, You-Cheng
    Contributors: 保健營養生技學系
    Date: 2014-01
    Issue Date: 2014-06-03 19:22:39 (UTC+8)
    Abstract: Ethnopharmacological relevance
    Antrodia salmonea (AS) is known as a traditional Chinese medicine, but very few biological activities have been reported.

    Materials and methods
    The present study was aimed to investigate the anti-angiogenic and anti-atherosclerotic potential of the fermented culture broth of AS against tumor necrosis factor-α (TNF-α)-stimulated human endothelial (EA.hy 926) cells.

    Results
    The non-cytotoxic concentrations of AS significantly inhibited TNF-α-induced migration/invasion and capillary-like tube formation in EA.hy 926 cells. Furthermore, AS suppressed TNF-α-induced activity and expression of matrix metalloproteinase-9 (MMP-9), and cell-surface expression of intercellular adhesion molecule-1 (ICAM-1), which was associated with abridged adhesion of U937 leukocytes to endothelial cells. Moreover, AS significantly down-regulated TNF-α-induced nuclear translocation and transcriptional activation of nuclear factor κB (NF-κB) followed by suppression of I-κB degradation and phosphorylation of I-κB kinase-α (IKKα). Notably, the protective effect of AS was directly correlated with the increased expression of hemeoxygenase-1 (HO-1) and γ-glutamylcysteine synthetase (γ-GCLC), which was reasoned by nuclear translocation and transactivation of NF-E2 related factor-2 (Nrf2)/antioxidant response element (ARE). Furthermore, HO-1 knockdown by HO-1-specific shRNA diminished the protective effects of AS on TNF-α-stimulated invasion, tube formation, and U937 adhesion in EA.hy 926 cells.

    Conclusions
    Taken together, these results suggest that Antrodia salmonea may be useful for the prevention of angiogenesis and atherosclerosis.
    Relation: JOURNAL OF ETHNOPHARMACOLOGY; 151(1):394–406
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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