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|Title: ||One-flask synthesis of 1,3,5-trisubstituted 1,2,4- triazoles from nitriles and hydrazonoyl chlorides via 1,3-dipolar cycloaddition|
|Authors: ||Wang, Li-Ya;Wang, Li-Ya;蔡建鈞;Tsai, Henry J;Lin, Hui-Yi;Lin, Hui-Yi;Ka, Kimiyoshi;Kaneko, Kimiyoshi;Che, Fen-Ying;Cheng, Fen-Ying;Sh, Hsin-Siao;Shih, Hsin-Siao;Won, Fung Fuh;Wong, Fung Fuh;Hu, Jiann-Jyh;Huang, Jiann-Jyh|
|Keywords: ||1,2,4-Triazoles, aldehydes, hydrazonoes, nitrilimine, 1,3-dipolar
|Issue Date: ||2014-06-03 19:25:42 (UTC+8)|
|Abstract: ||A new “one-flask” synthesis of 3,5-disubstituted 1,2,4-triazoles has
successfully been developed to synthesize a series of 3,5-disubstituted 1,2,4-triazoles.
The transformation involves the 1,3-dipolar cycloaddition reaction of hydrazonoyl
hydrochlorides with oxime intermediates prepared from aldehydes with
hydroxylamine hydrochloride in the presence of excess amount of triethylamine. In
this “one-flask” 1,3-dipolar reaction, hydrazonoyl hydrochlorides was concerned as
the masked 1,3-dipole nitrilimine under basic condition. Furthermore, this newly
developed methodology can be applied to various aldehyde substrates including
aliphatic, cyclic aliphatic, aromatic, and heterocyclic aldehydes.
|Relation: ||RSC Advances; 11:7834-7837|
|Appears in Collections:||[食品營養與保健生技學系] 期刊論文|
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