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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79534


    Title: Resistance to Irinotecan;CPT-11 activates Epidermal Growth Factor Receptor/Nuclear Factor Kappa B and Increases Cellular Metastasis and Autophagy in LoVo Colon Cancer Cells
    Authors: Ming-Cheng, C;Chen, Ming-Cheng;Le, Nien-Hung;Lee, Nien-Hung;Tsung-Jung, H;Ho, Tsung-Jung;Hs, Hsi-Hsien;Hsu, Hsi-Hsien;郭家驊;郭薇雯;Lin, Yueh-Min;Lin, Yueh-Min;蔡輔仁;Tsai, Fuu-Jen;蔡長海;黃志揚;HUANG, CHIH-YANG
    Contributors: 生物科技學系
    Keywords: Autophagy;CPT-11;Chemoresistance;Metastasis;NF-κB
    Date: 2014
    Issue Date: 2014-06-04 10:12:54 (UTC+8)
    Abstract: Chemotherapy is usually applied to treat colon cancer but leads to chemoresistance, and increased metastasis and invasion. The main focus of this study is to observe effects of resistance to irinotecan (CPT-11) on metastasis, invasion and autophagy in CPT-11 resistant (CPT-11-R) LoVo colon cancer cells. CPT-11, a topoisomerase I inhibitor and a first-line chemotherapeutic drug, is used to treat colon cancer. CPT-11-R cells were constructed in a step-wise fashion with increasing CPT-11 doses. The CPT-11-R strain had a significantly lower expression of Wnt/β-catenin pathway, but induced an EGFR/IKKα/β/NF-κB pathway with elevated cell cycle, metastasis and basal autophagy.
    Relation: CANCER LETTERS, 349(1):51-60
    Appears in Collections:[生物科技學系] 期刊論文

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