English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90453/105671 (86%)
Visitors : 15682764      Online Users : 146
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79536

    Title: Proliferative effects of chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent
    Authors: Hua, Kun Shan;Huang, Kun Shan;Lu, Min-Jin;Lu, Min-Jin;陳悅生;Chen, Yueh-Sheng;蔡輔仁;Tsai, Fuu-Jen;黃志揚;HUANG, CHIH-YANG;Che, Yi-Chang;Cheng, Yi-Chang;林建仲;Lin, Chien-Chung;蔡長海
    Contributors: 生物科技學系
    Keywords: Chishao;Proliferative Effect;Schwann Cells;Nerve Regeneration
    Date: 2014
    Issue Date: 2014-06-04 10:13:11 (UTC+8)
    Abstract: This study evaluated the proliferative effects of chishao on RSC96, Schwann cells. A dose-dependent proliferative effect of chishao was obtained by methylthiazol tetrazolium (MTT), proliferating cell nuclear antigen (PCNA) Western blotting, and wound healing assays in Schwann cells administered with chishao (0-500 mg/ml), except at 500 mg/ml concentration. The chishao-treated cells also showed a dose-dependent activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA) and decreased plasminogen activator inhibitor-1 (PAI-1), enhanced proliferative proteins, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-signaling. Using mitogen-actvated protein kinase (MAPK)-signaling chemical inhibitors, U0126, SB203580, and SP600125, the proliferative effects of chishao on RSC cells were identified to be ERK- and JNK- signaling dependent. Based on the results, applying appropriate doses of chishao to Schwann cells would be a potential approach for enhancing neuron regeneration.
    Relation: AMERICAN JOURNAL OF CHINESE MEDICINE;37(6):1191-202.
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback