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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79543


    Title: Cardiac Hypertrophy-related Pathways in Obesity
    Authors: Che, Wei-Kung;Chen, Wei-Kung;Yeh, Yu-Lan;Yeh, Yu-Lan;Lin, Yueh-Min;Lin, Yueh-Min;Li, Jing-Ying;Lin, Jing-Ying;Tza, Bor-Show;Tzang, Bor-Show;James, A.Lin;James, A.Lin;Yang, Ai-Lun;Yang, Ai-Lun;Wu, Fong-Li;Wu, Fong-Li;蔡輔仁;Tsai, Fuu-Jen;黃志揚;HUANG, CHIH-YANG;李信達;Lee, Shin-Da
    Contributors: 生物科技學系
    Date: 2014
    Issue Date: 2014-06-04 10:14:13 (UTC+8)
    Abstract: Obesity is often associated with the development of cardiac hypertrophy but the hypertrophyrelated pathways in obesity remain unknown. The purpose of this study was to evaluate cardiac hypertrophy-related markers, atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), tumor necrosis factor-alpha (TNFα) and hypertrophy-related pathways, interleukin (IL)-6-STAT3, IL-6-MEK5-ERK5 and calcineurin-nuclear factor of activated T-cells (NFAT)3 in the excised hearts from obese rats. Twelve obese Zucker rats were studied at 5-6 months of age and twelve age-matched lean Zucker rats served as the control group. The cardiac characteristics, myocardial architecture, ANP, BNP, TNFα levels, IL-6, STAT3, p-STAT3, MEK5, ERK-5, p-ERK-5, calcineurin and NFAT3 in the left ventricle from the rats were measured by heart weight index, echocardiography, vertical cross section, histological analysis, reverse transcription polymerase chain reaction and western blotting. Compared with the lean control, the whole heart weight, the left ventricule weight, the ratio of the whole heart weight to tibia length, echocardiographic interventricular septum, left ventricular posterior wall thickness, myocardial morphological changes and systolic blood pressure were found to increase in the obese rats. The protein levels of ANP, BNP, TNFα, IL-6, STAT3, p-STAT3, MEK-5, ERK-5, p-ERK 5, calcineurin and NFAT3 were also significantly increased in the hearts of the obese rats. The results showed that the hypertrophy-related markers, ANP, BNP and TNFα, the hypertrophy-related pathways IL-6-STAT3 and IL-6-MEK5-ERK5, and the calcineurin-NFAT3 hypertrophy-related pathways were more active in obese Zucker rats, which may provide possible hypertrophic mechanisms for developing cardiac hypertrophy and pathological changes in obesity.
    Relation: CHINESE JOURNAL OF PHYSIOLOGY, 57(3):111-120.
    Appears in Collections:[生物科技學系] 期刊論文

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