ASIA unversity:Item 310904400/79550
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90429/105609 (86%)
Visitors : 10575653      Online Users : 533
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79550


    Title: Association of Genetic Variants in Senataxin and Alzheimer’s Disease in a Chinese Han Population in Taiwan
    Authors: She, Che-Piao;Shen, Che-Piao;Lin, Wei-Yong;Lin, Wei-Yong;Li, Ting-Fang;Lin, Ting-Fang;Wang, Wen-Fu;Wang, Wen-Fu;Tsa, Chon-Haw;Tsai, Chon-Haw;Hsu, Ban-Dar;Hsu, Ban-Dar;黃志揚;HUANG, CHIH-YANG;Li, Hsin-Ping;Liu, Hsin-Ping;蔡輔仁;Tsai, Fuu-Jen
    Contributors: 生物科技學系
    Keywords: Alzheimer’s disease;DNA repair;polymorphism;senataxin;transcription
    Date: 2014
    Issue Date: 2014-06-04 10:15:26 (UTC+8)
    Abstract: Development of Alzheimer’s disease (AD) is characterized by progressive neuronal death and
    a decline in learning and memory. Mutations in human senataxin (SETX), an ortholog yeast protein
    of Sen1, have been identified to cause the syndrome of ataxia with oculomotor apraxia type 2 (AOA2)
    and juvenile amyotrophic lateral sclerosis (ALS4), two types of progressive motor neuron degenera-
    tion. However, the relationship between the SETX gene, which is involved in the regulation of RNA
    processing and DNA repair, and the predisposition for AD remains unclear. In this research, potential
    association of polymorphisms in the SETX gene with AD was investigated. A case-control study of a
    Chinese Han population in Taiwan was performed. Three single-nucleotide polymorphisms (SNPs),
    3455T>G (rs3739922), 3576T>G (rs1185193) and 7759A>G (rs1056899) were studied. The experimental
    data showed that upon genotyping of the exonic polymorphism in the SETX gene, the T allele appeared
    at a lower rate than the G allele at position 3455 in AD patients compared with normal groups (P < 0.05,
    odds ratio (OR), 0.59, 95% confidence interval (CI), 0.40-0.89). Subjects with the GA genotype at position
    7759 have higher incidences of AD development than with the AA genotype (P < 0.05, OR, 6.45, 95%
    CI, 1.24 to 33.70). Our results also showed that with six haplotypes (Hts) observed from the analyzed
    polymorphisms, distributions of the Ht4-GAA and Ht5-GCA haplotypes appeared to be significant ‘risk’
    haplotypes between AD patients and controls (both P < 0.05, OR, 8.44, 95% CI, 1.07-66.60). These ob-
    servations suggest that genetic variations in the SETX gene may contribute to AD pathogenesis in the
    Taiwanese Han population.
    Relation: CHINESE JOURNAL OF PHYSIOLOGY, V.57(2): 83-89
    Appears in Collections:[Department of Biotechnology] Journal Article

    Files in This Item:

    File SizeFormat
    index.html0KbHTML194View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback