ASIA unversity:Item 310904400/79550
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 90437/105768 (86%)
造訪人次 : 10939416      線上人數 : 597
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋


    題名: Association of Genetic Variants in Senataxin and Alzheimer’s Disease in a Chinese Han Population in Taiwan
    作者: She, Che-Piao;Shen, Che-Piao;Lin, Wei-Yong;Lin, Wei-Yong;Li, Ting-Fang;Lin, Ting-Fang;Wang, Wen-Fu;Wang, Wen-Fu;Tsa, Chon-Haw;Tsai, Chon-Haw;Hsu, Ban-Dar;Hsu, Ban-Dar;黃志揚;HUANG, CHIH-YANG;Li, Hsin-Ping;Liu, Hsin-Ping;蔡輔仁;Tsai, Fuu-Jen
    貢獻者: 生物科技學系
    關鍵詞: Alzheimer’s disease;DNA repair;polymorphism;senataxin;transcription
    日期: 2014
    上傳時間: 2014-06-04 10:15:26 (UTC+8)
    摘要: Development of Alzheimer’s disease (AD) is characterized by progressive neuronal death and
    a decline in learning and memory. Mutations in human senataxin (SETX), an ortholog yeast protein
    of Sen1, have been identified to cause the syndrome of ataxia with oculomotor apraxia type 2 (AOA2)
    and juvenile amyotrophic lateral sclerosis (ALS4), two types of progressive motor neuron degenera-
    tion. However, the relationship between the SETX gene, which is involved in the regulation of RNA
    processing and DNA repair, and the predisposition for AD remains unclear. In this research, potential
    association of polymorphisms in the SETX gene with AD was investigated. A case-control study of a
    Chinese Han population in Taiwan was performed. Three single-nucleotide polymorphisms (SNPs),
    3455T>G (rs3739922), 3576T>G (rs1185193) and 7759A>G (rs1056899) were studied. The experimental
    data showed that upon genotyping of the exonic polymorphism in the SETX gene, the T allele appeared
    at a lower rate than the G allele at position 3455 in AD patients compared with normal groups (P < 0.05,
    odds ratio (OR), 0.59, 95% confidence interval (CI), 0.40-0.89). Subjects with the GA genotype at position
    7759 have higher incidences of AD development than with the AA genotype (P < 0.05, OR, 6.45, 95%
    CI, 1.24 to 33.70). Our results also showed that with six haplotypes (Hts) observed from the analyzed
    polymorphisms, distributions of the Ht4-GAA and Ht5-GCA haplotypes appeared to be significant ‘risk’
    haplotypes between AD patients and controls (both P < 0.05, OR, 8.44, 95% CI, 1.07-66.60). These ob-
    servations suggest that genetic variations in the SETX gene may contribute to AD pathogenesis in the
    Taiwanese Han population.
    顯示於類別:[生物科技學系] 期刊論文


    檔案 大小格式瀏覽次數


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋