ASIA unversity:Item 310904400/79552
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90120/105278 (86%)
造访人次 : 8950167      在线人数 : 76
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/79552


    题名: Hepatitis B Virus X Upregulates HuR Protein Level to Stabilize HER2 Expression in Hepatocellular Carcinoma Cells
    作者: Hu, Chao-Ming;Hung, Chao-Ming;黃偉謙;Huang, Wei-Chien;Pa, Hsiao-Lin;Pan, Hsiao-Lin;Ch, Pei-Hsuan;Chien, Pei-Hsuan;Lin, Chih-Wen;Lin, Chih-Wen;Che, Lei-Chin;Chen, Lei-Chin;Chie, Yu-Fong;Chien, Yu-Fong;Ching-Chiao;Lin, Ching-Chiao;Chen, Jhen-Yu;Chen, Jhen-Yu;Ho, Chien-Yi;Ho, Chien-Yi;Ho, Pao-Sheng;Hou, Pao-Sheng
    贡献者: 生物科技學系
    日期: 2014-02
    上传时间: 2014-06-04 10:15:48 (UTC+8)
    摘要: Hepatitis B virus- (HBV-) associated hepatocellular carcinoma (HCC) is the most common type of liver cancer. However, the underlying mechanism of HCC tumorigenesis is very complicated and HBV-encoded X protein (HBx) has been reported to play the most important role in this process. Activation of downstream signal pathways of epidermal growth factor receptor (EGFR) family is known to mediate HBx-dependent HCC tumor progression. Interestingly, HER2 (also known as ErbB2/Neu/EGFR2) is frequently overexpressed in HBx-expressing HCC patients and is associated with their poor prognosis. However, it remains unclear whether and how HBx regulates HER2 expression. In this study, our data showed that HBx expression increased HER2 protein level via enhancing its mRNA stability. The induction of RNA-binding protein HuR expression by HBx mediated the HER2 mRNA stabilization. Finally, the upregulated HER2 expression promoted the migration ability of HBx-expressing HCC cells. These findings deciphered the molecular mechanism of HBx-mediated HER2 upregulation in HBV-associated HCC.
    關聯: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
    显示于类别:[生物科技學系] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    index.html0KbHTML156检视/开启


    在ASIAIR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈