English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90451/105768 (86%)
Visitors : 11045848      Online Users : 570
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79574


    Title: High-resolution melting analyses for genetic variants in ARID5B and IKZF1 with childhood acute lymphoblastic leukemia susceptibility loci in Taiwan
    Authors: Lin, Chien-Yu;Lin, Chien-Yu;Li, Meng-Ju;Li, Meng-Ju;Ch, Jan-Gowth;Chang, Jan-Gowth;Liu, Su-Ching;Liu, Su-Ching;Weng, Tefu;Weng, Tefu;Wu, Kang-Hsi;Wu, Kang-Hsi;Yang, Shu-Fen;Yang, Shu-Fen;Huan, Fu-Kuei;Huang, Fu-Kuei;Lo, Wan-Yu;Lo, Wan-Yu;彭慶添;Peng, Ching-Tien
    Contributors: 生物科技學系
    Keywords: ARID5B;Childhood acute lymphoblastic leukemia;High-resolution melting analyses;IKZF1;Single nucleotide polymorphisms
    Date: 2014-02
    Issue Date: 2014-06-04 10:19:45 (UTC+8)
    Abstract: Background
    Childhood acute lymphoblastic leukemia (ALL), a heterogeneous disease that includes multiple subtypes is defined by cell lineage and chromosome anomalies. Previous genome-wide association studies have reported several ARID5B and IKZF1 single nucleotide polymorphisms (SNPs) associated with the incidence of ALL. High-resolution melting (HRM) analysis is a rapid and convenient technique to detect SNPs; we thereby detected SNPs in ARID5B and IKZF1 genes.

    Methods
    We enrolled 79 pediatric ALL patients and 80 healthy controls. Polymorphic variants of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs7073837, rs10740055, and rs7089424) were detected by HRM, and SNPs were analyzed for association with childhood ALL.

    Results
    The distribution of genotype rs7073837 in ARID5B significantly differed between ALL and controls (P = 0.046), while those of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs10740055 and rs7089424) did not. We analyzed the association for SNPs with B lineage ALL to find rs7073837 in ARID5B, conferring a higher risk for B lineage ALL (odds ratio, OR = 1.70, 95% confidence interval, CI = 1.01–2.87, P = 0.049).

    Conclusion
    HRM is a practical method to detect SNPs in ARID5B and IKZF1 genes. We found that rs7073837 in ARID5B correlated with a risk for childhood B lineage ALL.
    Relation: BLOOD CELLS MOLECULES AND DISEASES, V.52 N.2–3:140–145.
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File SizeFormat
    index.html0KbHTML107View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback