ASIA unversity:Item 310904400/79620
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    題名: Lead Screening for HIV of C-C Chemokine Receptor Type 5 Receptor Inhibited by Traditional Chinese Medicine
    作者: Hu, Tzu-Chieh;Hung, Tzu-Chieh;Che, Kuen-Bao;Chen, Kuen-Bao;Hua, Hung-Jin;Huang, Hung-Jin;陳語謙;Chen, Calvin Yu-chian
    貢獻者: 生物科技學系
    日期: 2014-04
    上傳時間: 2014-06-04 10:26:38 (UTC+8)
    摘要: The acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), has become a serious world-wide problem because of this disease's rapid propagation and incurability. Recent research has pointed out that the C-C chemokine receptor type 5 (CCR5) is an important target for HIV infection. The traditional Chinese medicine (TCM) database (http://tcm.cmu.edu.tw/) has been screened for molecular compounds that, by simulating molecular docking and molecular dynamics, may protect CCR5 against HIV. Saussureamine C, 5-hydroxy-L-tryptophan, and abrine are selected based on the docking score being higher than Maraviroc and other TCM compounds. The molecular dynamics are helpful in the analysis and detection of protein-ligand interactions. According to the docking poses, hydrophobic interactions, and hydrogen bond variations, this research surmises TRP86, TYR108, GLN194, TYR251, and GLU283 are the main regions of important amino acids in CCR5. In addition to the detection of TCM compound efficacy, we suggest saussureamine C is better than the others for maintaining protein composition during protein-ligand interaction, based on the structural variation.
    關聯: Evidence-based Complementary and Alternative Medicine
    顯示於類別:[生物科技學系] 期刊論文

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