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    ASIA unversity > 管理學院 > 國際企業學系 > 期刊論文 >  Item 310904400/79651


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79651


    Title: Induction of Apoptosis in Human DU145 Prostate Cancer Cells by KHC-4 Treatment
    Authors: Tien-Huang Lin;Wen-Chi Chen;Hsi-Chin Wu;Wen-Shin Chien;Shang-Seu Lee;Fu-Jenn Tsai;Chang-Hai Tsai;Wei-Jen Ting;Sheng-Chu Kuo;Chih-Yang Huang
    Contributors: 生物科技學系
    Keywords: anti-tumor effects;apoptosis;2’-fluoro-6-morpholinyl-2-phenyl-4-quinolone;prostate cancer
    Date: 2014-04
    Issue Date: 2014-06-05 11:48:00 (UTC+8)
    Abstract: Prostate cancer (CaP) is one of the most prevalent cancers worldwide and the incidence and mortality rates have been rapidly increasing in recent years in Taiwan. Therefore, it is important to development anti-cancer therapy. In this study, KHC-4 was identified from 2-phenyl-4-quionolone derivatives in human prostate cancer cells and as a potential antitumor agent. In this study, we have identified KHC-4 induced apoptosis effects in castration-resistant prostate cancer DU145 cells, and the IC50 value of KHC-4 was 0.1 μM. KHC-4 suppressed the survival signaling p-PI3K and p-Akt and protein levels of Bcl-2 and Bcl-xL, upregulated Bax, cytochrome c and caspase 8/9 and induced apoptosis by mitochondrial-dependent pathway. In JC-1 assay monitored the loss of membrane potential in KHC-4 treatments. TUNEL assay results showed DNA fragmentation in KHC-4 induced apoptosis.We concluded that KHC-4 exerted anti-tumor effects in DU145 cells by induction of apoptosis.
    Relation: CHINESE JOURNAL OF PHYSIOLOGY,57(2):99-104.
    Appears in Collections:[國際企業學系] 期刊論文

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