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    ASIA unversity > 管理學院 > 國際企業學系 > 期刊論文 >  Item 310904400/79652


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79652


    Title: GABA Tea Prevents Cardiac Fibrosis by Attenuating TNF-alpha and Fas/FasL-mediated apoptosis in Streptozotocin-Induced Diabetic Rats
    Authors: Shur-Hueih Cherng;黃志揚;CHIH-YANG HUANG;Wei-Wen Kuo;Shue-Er Lai;Chien-Yu Tseng;Yueh-Min Lin;蔡輔仁;Tsai, Fuu-Jen;Hsueh-Fang Wang
    Contributors: 生物科技學系
    Keywords: GABA tea;Diabetes;Heart;Fas;TNF-alpha
    Date: 2014-03
    Issue Date: 2014-06-05 11:48:08 (UTC+8)
    Abstract: GABA tea is a tea product that contains a high level of gamma-aminobutyric acid (GABA). This study investigated the effects of GABA tea on the heart in a diabetic rat model. Male Wistar rats were injected with 55 mg/kg streptozotocin (STZ) to induce diabetes for 2 weeks and then orally given dosages of 4.55 and 45.5 mg/kg/day GABA tea extract for 6 weeks. The results revealed that fasting blood glucose levels returned to normal levels in GABA tea-treated diabetic rats, but not in the untreated diabetic rats. Additionally, GABA tea effectively inhibited cardiac fibrosis induced by STZ. Further experiments showed that the STZ-induced protein levels of tumor necrosis factor-alpha (TNF-alpha), Fas, activated caspase-8 and caspase-3 were significantly inhibited by the GABA tea treatment. Therefore, our data suggest that the inhibiting effect of GABA tea on STZ-induced cardiac fibrosis in diabetic rats may be mediated by reducing blood glucose and further attenuating TNF-alpha expression and/or Fas/Fas ligand (FasL)-mediated apoptosis. These findings will provide implications for the potential anti-diabetic properties of GABA tea.
    Relation: FOOD AND CHEMICAL TOXICOLOGY,65,90-96.
    Appears in Collections:[國際企業學系] 期刊論文

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