Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts.

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Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79658

Title:	Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts.
Authors:	Jeng-Shyan Deng;Shin-Da Lee;Wei-Wen Kuoc, Ming-Jen Fan;Yueh-Min Lin;Wei-Syun Hu;Yi-Ching Huang;Bharath Kumar Velmurugan;Fuu-Jen Tsai;Chang-Hai Tsai;Chih-Yang Huang
Contributors:	生物科技學系
Keywords:	Caspase;Cell death;Fas receptor;Heart;Hypertension;Mitochondrial
Date:	2014-02
Issue Date:	2014-06-05 11:49:01 (UTC+8)
Abstract:	Cardiac apoptosis was found in hearts from hypertensive animals, therefore in this study we aimed to evaluate the anti-apoptotic and pro-survival effects of protocatechuic acid (PCA) on hypertensive hearts. At first we found that, sedentary group (SHR)-PCA group's decreased TUNEL-positive apoptotic cells than SHR group alone. Protein levels of Fas ligand, Fas death receptor, Fas-associated death domain (FADD), Bid, t-Bid, Bax, cytochrome c, activated caspase-8, activated caspase 9 and activated caspase-3 were decreased in SHR-PCA group compared with SHR group. Moreover, SHR-PCA groups increased pro-survival pathway proteins like IGF1, pIGF1R, pPI3K, p-Akt, Bcl-xL, and Bcl-2 than SHR and sedentary normotensive group (WKY). All these finding suggest us that, Protocatechuic acid prevented hypertension-enhanced cardiac Fas-dependent and mitochondria-dependent apoptotic pathways and enhanced cardiac pro-survival pathway in rat models. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Relation:	CHEMICO-BIOLOGICAL INTERACTIONS,209,77–84.
Appears in Collections:	[國際企業學系] 期刊論文

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