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    ASIA unversity > 管理學院 > 國際企業學系 > 期刊論文 >  Item 310904400/79682


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/79682


    Title: Trichostatin A Suppresses EGFR Expression through Induction of MicroRNA-7 in an HDAC-Independent Manner in Lapatinib-Treated Cells.
    Authors: Chih-Yen Tu;Chia-Hung Chen;Te-Chun Hsia;Min-Hsiang Hsu;Ya-Ling Wei;Meng-Chieh Yu;Wen-Shu Chen;Ke-Wei Hsu;Ming-Hsin Yeh;Liang-Chih Liu;Yun-Ju Chen;Wei-Chien Huang
    Contributors: 生物科技學系
    Date: 2014-02
    Issue Date: 2014-06-05 11:52:43 (UTC+8)
    Abstract: Lapatinib, a dual EGFR/HER2 tyrosine kinase inhibitor, has been shown to improve the survival rate of patients with advanced HER2-positive breast cancers. However, the off-target activity of lapatinib in inducing EGFR expression without tyrosine kinase activity was demonstrated to render HER2-negative breast cancer cells more metastatic, suggesting a limitation to the therapeutic effectiveness of this dual inhibitor in HER2-heterogeneous tumors. Therefore, targeting EGFR expression may be a feasible approach to improve the anticancer efficiency of lapatinib-based therapy. Inhibition of HDAC has been previously reported to epigenetically suppress EGFR protein expression. In this study, however, our data indicated that treatment with HDAC inhibitors trichostatin A (TSA), but not suberoylanilide hydroxamic acid (SAHA) or HDAC siRNA, can attenuate both protein and mRNA expressions of EGFR in lapatinib-treated triple-negative breast cancer cells, suggesting that TSA may suppress EGFR expression independently of HDAC inhibition. Nevertheless, TSA reduced EGFR 3′UTR activity and induced the gene expression of microRNA-7, a known EGFR-targeting microRNA. Furthermore, treatment with microRNA-7 inhibitor attenuated TSA-mediated EGFR suppression. These results suggest that TSA induced microRNA-7 expression to downregulate EGFR expression in an HDAC-independent manner.
    Relation: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
    Appears in Collections:[國際企業學系] 期刊論文

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