ASIA unversity:Item 310904400/79848
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    ASIA unversity > 管理學院 > 國際企業學系 > 期刊論文 >  Item 310904400/79848


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    题名: In Silico Design of BACE1 Inhibitor for Alzheimer’s Disease by Traditional Chinese Medicine
    作者: Hung-Jin Huang;Cheng-Chun Lee;Calvin Yu-Chian Chen
    贡献者: 生物科技學系
    日期: 2014-05
    上传时间: 2014-06-05 12:18:39 (UTC+8)
    摘要: The β-site APP cleaving enzyme 1 (BACE1) is an important target for causing Alzheimer's disease (AD), due to the brain deposition peptide amyloid beta (Aβ) require cleavages of amyloid precursor protein (APP) by BACE1 and γ-secretase, but treatments of AD still have side effect in recent therapy. This study utilizes the world largest traditional Chinese medicine (TCM) database and database screening to provide potential BACE1 inhibited compound. Molecular dynamics (MD) simulation was carried out to observe the dynamics structure after ligand binding. We found that Triptofordin B1 has less toxicity than pyrimidine analogue, which has more potent binding affinity with BACE1. For trajectory analysis, all conformations are tending to be stable during 5000 ps simulation time. In dynamic protein validation, the residues of binding region are still stable after MD simulation. For snapshot comparison, we found that Triptofordin B1 could reduce the binding cavity; the results reveal that Triptofordin B1 could bind to BACE1 and better than control, which could be used as potential lead drug to design novel BACE1 inhibitor for AD therapy.
    關聯: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
    显示于类别:[國際企業學系] 期刊論文

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