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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/81129


    Title: Paeonol suppress chondrosarcoma metastasis through up-regulation of miR-141 by modulating the PKC? and c-Src signaling pathway
    Authors: Hor, Chi-Ting;Horng, Chi-Ting;Shi, Po-Chuen;Shieh, Po-Chuen;Tan, Tzu-Wei;Tan, Tzu-Wei;Yan, Wei-Hung;Yang, Wei-Hung;湯智昕;Chih-Hsin, Tang;*
    Contributors: 生物科技學系
    Keywords: paeonol;chondrosarcoma;miR-141;metastasis
    Date: 2014-07
    Issue Date: 2014-10-01 16:31:59 (UTC+8)
    Abstract: Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of traditional Chinese remedy Paeonia lactiflora Pallas, exhibits anti-inflammatory and anti-tumor activity; whether paeonol regulates metastatic chondrosarcoma is largely unknown. Here, we find paeonol do not increase apoptosis. By contrast, at non-cytotoxic concentrations, paeonol suppresses migration and invasion of chondrosarcoma cells. We also demonstrate paeonol enhancing miR-141 expression and miR-141 inhibitor reversing paeonol-inhibited cell motility; paeonol also reduces protein kinase C (PKC)δ and c-Src kinase activity. Since paeonol inhibits migration and invasion of human chondrosarcoma via up-regulation of miR-141 via PKCδ and c-Src pathways, it thus might be a novel anti-metastasis agent for treatment of metastatic chondrosarcoma.
    Relation: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; 15(7): 11760–11772.
    Appears in Collections:[生物科技學系] 期刊論文

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