ASIA unversity:Item 310904400/81135
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    题名: Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects
    作者: Chang, YW;Chang, YW;Su, CM;Su, CM;Su, YH;Su, YH;Ho, YS;Ho, YS;Lai, HH;Lai, HH;Chen, HA;Chen, HA;Kuo, ML;Kuo, ML;Hung, WC;Hung, WC;Wu CH,;Chen, PS;Chen, PS;蘇振良*
    贡献者: 生物科技學系
    日期: 2014-06
    上传时间: 2014-10-01 16:32:49 (UTC+8)
    摘要: Vascular endothelial growth factor receptor 3 (VEGFR-3) supports tumor lymphangiogenesis. It was originally identified as a lymphangiogenic factor expressed in lymphatic endothelial cells. VEGFR-3 was detected in advanced human malignancies and correlated with poor prognosis. Our previous studies show that activation of the VEGF-C/VEGFR-3 axis promotes cancer metastasis and is associated with clinical progression in patients with lung cancer, indicating that VEGFR-3 is a potential target for cancer therapy. In this study, we developed eight peptides targeting VEGFR-3. Two peptides strongly inhibited the kinase activity of VEGFR-3 and suppressed VEGF-C-mediated invasion of cancer cells. Moreover, these peptides abolished VEGF-C-induced drug resistance and tumor initiating cell formation. This study demonstrates the therapeutic potential of VEGFR-3-targeting peptides.
    關聯: Oncotarget;5(11):3823-35.
    显示于类别:[生物科技學系] 期刊論文

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