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|Title: ||Hypolipidemic activity of Taraxacum mongolicum associated with the activation of AMP-activatedprotein kinase in human HepG2 cells|
|Authors: ||Liu, Yan-Jin;Liu, Yan-Jin;Shi, Po-Chuen;Shieh, Po-Chuen;Jang-Chang, L;Lee, Jang-Chang;Chen, Fu-An;Chen, Fu-An;Le, Chih-Hung;Lee, Chih-Hung;Ku, Sheng-Chu;Kuo, Sheng-Chu;Ho, Chi-Tang;Ho, Chi-Tang;Daih-Huang, K;Kuo, Daih-Huang;Huan, Li-Jiau;Huang, Li-Jiau;魏宗德;Way, Tzong-Der;*|
|Issue Date: ||2014-10-01 16:47:41 (UTC+8)|
|Abstract: ||This study investigated the hypolipidemic effect and potential mechanisms of T. mongolicum extracts. T. mongolicum was extracted by refluxing three times with water (TM-1), 50% ethanol (TM-2) and 95% ethanol (TM-3). TM-2 contained components with the most effective hypolipidemic potentials in HepG2 cells. Extended administration of TM-2 stimulated a significant reduction in body weight and levels of serum triglyceride LDL-C and total cholesterol in rats. To evaluate the bioactive compounds, we successively fractionated TM-2 with n-hexane (TM-4), dichloromethane (TM-5), ethyl acetate (TM-6), and water (TM-7). TM-4 fraction had the most effective hypolipidemic potential in HepG2 cells, and it decreased the expression of fatty acid synthase (FASN) and inhibited the activity of acetyl-coenzyme A carboxylase (ACC) through the phosphorylation of AMP-activated protein kinase (AMPK). Linoleic acid, phytol and tetracosanol are bioactive compounds identified from TM-4. These results suggest that T. mongolicum is expected to be useful for hypolipidemic effects.|
|Relation: ||Food and Function;5(8):1755-62.|
|Appears in Collections:||[食品營養與保健生技學系] 期刊論文|
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