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http://asiair.asia.edu.tw/ir/handle/310904400/81161
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| Title: | Diterpene Glycosides and Polyketides from Xylotumulus gibbisporus |
| Authors: | 張雅植;Chang, Ya-Chih;盧重光;Lu, Chung-Kuang;Chian, Yin-Ru;Chiang, Yin-Ru;汪貴珍;Wang, Guei-Jane;Ju, Yu-Ming;Ju, Yu-Ming;Yueh-Hsiung;Kuo, Yueh-Hsiung;Tzong-Huei, L;Lee, Tzong-Huei |
| Contributors: | 保健營養生技學系 |
| Date: | 2014-04 |
| Issue Date: | 2014-10-01 16:48:02 (UTC+8) |
| Abstract: | Four new tetracyclic diterpene glycosides, namely, sordarins C-F (1-4), and three new γ-lactone polyketides, namely, xylogiblactones A-C (5-7), along with sordarin were isolated from the ethyl acetate extracts of the fermented broths of Xylotumulus gibbisporus YMJ863. The structures of 1-7 were elucidated on the basis of spectroscopic data analyses. The configurations of 1-4 were deduced by NOESY, molecular modeling, and comparison with the literature. The relative configurations of 5-7 were deduced by X-ray crystallographic analysis of 5. Compounds 1-5 and sordarin were evaluated in an antifungal assay using Candida albicans ATCC 18804, C. albicans ATCC MYA-2876, and Saccharomyces cerevisiae ATCC 2345, and only sordarin exhibited significant antifungal activities against these fungal strains, with MIC values of 64.0, 32.0, and 32.0 μg/mL, respectively. The effect of compounds 1-7 and sordarin on the inhibition of NO production in lipopolysaccharide-activated murine macrophages was also evaluated. Compounds 2 and sordarin inhibited NO production with IC50 values of 327.2±46.6 and 157.1±24.1 μM, respectively. |
| Relation: | JOURNAL OF NATURAL PRODUCTS; 77(4):751-7. |
| Appears in Collections: | [食品營養與保健生技學系] 期刊論文
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