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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8127


    Title: A Probabilistic Method to Correlate Ion-pairs to Protein Thermostability
    Authors: S. L. Huang;L. C. Wu;Laing, K. T. Pan;M. T. Ko;J. T. Horng
    Contributors: Department of Bioinformatics
    Keywords: Ion-Pairs;Protein Thermostability;Bayesian
    Date: 2004
    Issue Date: 2010-03-19 16:24:29 (UTC+8)
    Publisher: Asia University
    Abstract: Recent developments in research on the stability of proteins show that ion-pairs potentially contribute to the thermostability of proteins, according to comparisons of ion-pairs between homologous structures. This study proposes a probabilistic Bayesian statistical method to predict
    efficiently the thermostability of proteins based on considering the properties of ion-pairs. The experimental results suggest that the number, types, and bond distance of ion-pairs can be used to predict thermostability of proteins with functions similar to each other with a high accuracy up to 80%. The predictions have high precision of 99%, especially for hyperthermophilic proteins. The experimental results of proteins with different functions also indicate that the number of ion-pairs is related to the thermostability of proteins, and predictions of thermostability can also be made for proteins with different functions.
    Relation: Applied Bioinformatics 3 (1): 21-29
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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