ASIA unversity:Item 310904400/8200
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    题名: Immunotherapy of breast cancer by single delivery with rAAV2-mediated interleukin-15 expression
    作者: Yu, YL (Yu, Yung-Luen);Wei, CW (Wei, Chyou-Wei);Chen, YL (Chen, Yi-Lin);Chen, MHC (Chen, Mark Hung-Chih);Yiang, GT (Yiang, Giou-Teng)
    贡献者: Department of Biotechnology
    关键词: RECOMBINANT ADENOASSOCIATED VIRUS;ACTIVATED KILLER-CELLS;GENE-THERAPY;TUMOR-GROWTH;IN-VIVO;IL-15;VECTORS;PURIFICATION;LYMPHOCYTES;SUPPRESSION
    日期: 2010-02
    上传时间: 2010-03-26 10:28:59 (UTC+8)
    出版者: Asia University
    摘要: Recombinant adenovirus-associated vector serotype 2 (rAAV2) is one of the most promising gene transfer vectors due to its advantage of causing non-pathogenic infection, low immunogenicity, and long-term gene expression in human clinical trials. Human interleukin 15 (hIL15) has been implicated in modulation of antitumor activity of lymphokine-activated killer (LAK) cells, including T cells and NK cells. In this study, the rAAV2-hIL15 vector was produced and subjected for treatment with xenograft JC breast cancer model. Results showed that tumor onset was significantly delayed, the tumor growth was suppressed, and the lifespan of tumor-bearing mice were prolonged by rAAV2-h1L15. In addition, rAAV2-hIL15 was able to produce a substantial expression of IL15 protein that ultimately activated the cytotoxic activity of LAK cells. Furthermore, prominent apoptosis was observed in tumor lesions following injection of rAAV2-hIL15. Taken together, our results suggested that rAAV2-hIL15 appears as a new potential therapeutic tool for breast cancer immunotherapy.
    關聯: INTERNATIONAL JOURNAL OF ONCOLOGY 36 (2): 365-370
    显示于类别:[生物科技學系] 期刊論文

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