English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90453/105672 (86%)
Visitors : 11996226      Online Users : 344
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8232


    Title: Ganoderma lucidum Extracts Inhibited Leukemia WEHI-3 Cells in BALB/c Mice and Promoted an Immune Response in Vivo
    Authors: Chang, YH (Chang, Yung-Hsien);Yang, JS (Yang, Jai-Sing);Yang, JL (Yang, Jiun-Long);Wu, CL (Wu, Chang-Lin);Chang, SJ (Chang, Shu-Jen);Lu, KW (Lu, Kung-Wen);Lin, JJ (Lin, Jen-Jyh);Hsia, TC (Hsia, Te-Chun);Lin, YT (Lin, Yi-Ting);Ho, CC (Ho, Chin-Chih);Wood, WG (Wood, W. Gibson);Chung, JG (Chung, Jing-Gung)
    Contributors: Department of Biotechnology
    Keywords: BREAST-CANCER CELLS;CYCLE ARREST;APOPTOSIS;POLYSACCHARIDES;ANTITUMOR;PROLIFERATION;MECHANISMS;EXPRESSION;TRITERPENE;VITRO
    Date: 2009-12
    Issue Date: 2010-03-26 10:29:13 (UTC+8)
    Publisher: Asia University
    Abstract: Ganoderma lucidum (G. lucidum) is a medicinal mushroom having biological effects such as immuno-modulation and anti-tumor actions. In China and many other Asian countries, G. lucidum is used as a folk remedy to promote health and longevity. Although many studies have shown that G. lucidum modulates the immune system, including, for example, antigen-presenting cells, natural killer (NK) cells, and the T and B lymphocytes, the effects of G. lucidum on the WEHI-3 leukemic BALB/c mice are unclear. We attempted to determine whether G. lucidum would promote immune responses in BALB/c mice injected with WEHI-3 leukemia cells. The effects of G. lucidum on the survival rate of WEHI-3 leukemia cells injected into BALB/c mice were examined. It increased the percentages of CD3 and CD19, but decreased, the percentages of Mac-3 and CD11b markers, suggesting that differentiation of the precursor of T and B cells was promoted but macrophages were inhibited. It decreased the weight of spleens as compared with control mice. It also promoted phagocytosis by macrophage from peripheral blood mononuclear cell (PBMC) and it also promoted natural killer cell activity. It decreased the percentage of leukemia cells in the spleens of mice before they were injected with WEHI-3 cells. Apparently, G. lucidum affects murine leukemia WEHI-3 cells in vivo.
    Relation: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 73 (12): 2589-2594
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    117.docx0KbUnknown283View/Open
    117.doc44KbMicrosoft Word378View/Open


    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback