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    题名: Rhein Induced Apoptosis through the Endoplasmic Reticulum Stress, Caspase- and Mitochondria-dependent Pathways in SCC-4 Human Tongue Squamous Cancer Cells
    作者: Lai, WW (Lai, Wan-Wen);Yang, JS (Yang, Jai-Sing);Lai, KC (Lai, Kuang-Chi);Kuo, CL (Kuo, Chao-Lin);Hsu, CK (Hsu, Cheng-Kuang);Wang, CK (Wang, Chien-Kuo);Chang, CY (Chang, Ching-Yao);Lin, JJ (Lin, Jen-Jyh);Tang, NY (Tang, Nou-Ying);Chen, PY (Chen, Po-Yuan);Huang, WW (Huang, Wen-Wen);Chung, JG (Chung, Jing-Gung)
    贡献者: Department of Biotechnology
    关键词: Rhein;apoptosis;caspase;mitochondria;DNA damage;SCC-4 human tongue cancer cells;ACTIVATION;PROTEOLYSIS;PROTEASES
    日期: 2009-03
    上传时间: 2010-03-26 10:29:14 (UTC+8)
    出版者: Asia University
    摘要: Rhein, an anthraquinone compound, can be found in the rhizome of rhubarb, a traditional Chinese medicine herb showing antitumor activity. In this study, it was observed that rhein induced S-phase arrest through the inhibition of p53, cyclin A and E and it induced apoptosis through the endoplasmic reticulum stress by the production of reactive oxygen species (ROS) and Ca2+ release, mitochondrial dysfunction, and caspase-8, -9 and -3 activation in human tongue cancer cell line (SCC-4). The most efficient induction of apoptosis was observed at 30 mu M for 24 h. Mechanistic analysis demonstrated that rhein induced changes in the ratio of Bax/Bcl-2 based on the decrease of Bcl-2 levels, the loss of mitochondrial membrane potential, cytochrome c release from the mitochondria and the activation of caspase-9 and -3. The data demonstrated that rhein induces apoptosis in SCC-4 cells via caspase, ROS and mitochondrial death pathways.
    關聯: IN VIVO 23 (2): 309-316
    显示于类别:[生物科技學系] 期刊論文


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