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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8238

    Title: Interleukin-18 Gene 105A/C Genetic Polymorphism is Associated With the Susceptibility of Kawasaki Disease
    Authors: Chen, SY (Chen, Shih-Yin);Wan, L (Wan, Lei);Huang, YC (Huang, Yu-Chuen);Sheu, JJC (Sheu, Jim Jinn-Chyuan);Lan, YC (Lan, Yu-Ching);Lai, CH (Lai, Chih-Ho);Lin, CW (Lin, Cheng-Wen);Chang, JS (Chang, Jeng Sheng);Tsai, Y (Tsai, Yuhsin);Liu, SP (Liu, Shih-Ping);Lin, YJ (Lin, Ying-Ju);Tsai, FJ (Tsai, Fuu-Jen)
    Contributors: Department of Biotechnology
    Date: 2009
    Issue Date: 2010-03-26 10:29:15 (UTC+8)
    Publisher: Asia University
    Abstract: Interleukin-18 (IL-18)-656T/G, -607A/C, and -137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL-18 105A/C genetic polymorphism confers KD susceptibility. Study participants were Taiwanese KD patients and a healthy control group. Our data indicated that the frequency of C allele was significantly higher in the patient group (13.9%) than in the control group (2.7%; P<0.0001, odds ratio [OR] = 5.93; 95% confidence interval [CI] = 2.57-13.73). Therefore, persons with the C allele may have higher risk of deve loping KD. In addition, compared with the haplotype frequencies between case and control groups, the KD patients with TACC haplotype appeared to be a significant "at-risk" haplotype compared with other haplotypes (OR: 4.62, 95% CI: 1.71-12.43; P = 0.001). KD patient with the TAGA haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.51, 95% CI:0.29-0.89; P = 0.017). Our results suggest that 105A/C polymorphism and the haplotypes in IL-18 gene are associated with the risk of KD in Taiwanese population. Clin. Lab. Anal. 23:71-76, 2009. (C) 2009 Wiley-Liss, Inc.
    Appears in Collections:[生物科技學系] 期刊論文

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