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    Title: Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model
    Authors: Ho, YT (Ho, Yung-Tsuan);Yang, JS (Yang, Jai-Sing);Lu, CC (Lu, Chi-Cheng);Chiang, JH (Chiang, Jo-Hua);Li, TC (Li, Tsai-Chung);Lin, JJ (Lin, Jen-Jyh);Lai, KC (Lai, Kuang-Chi);Liao, CL (Liao, Ching-Lung);Lin, JG (Lin, Jaung-Geng);Chung, JG (Chung, Jing-Gung)
    Contributors: Department of Biotechnology
    Keywords: Berberine;Human tongue SCC-4 cancer cells;Xenograft transplantation;In vivo
    Date: 2009-09
    Issue Date: 2010-03-26 10:29:22 (UTC+8)
    Publisher: Asia University
    Abstract: Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10 mg/kg of body weight) and doxorubicin (4 mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4 mg/kg of doxorubicin or with 10 mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10 mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic. (c) 2009 Elsevier GmbH. All rights reserved.
    Relation: PHYTOMEDICINE 16 (9): 887-890
    Appears in Collections:[Department of Biotechnology] Journal Article

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