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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8296


    Title: Effects of Curcumin on N-bis(2-Hydroxypropyl) nitrosamine (DHPN)-induced Lung and Liver Tumorigenesis in BALB/c Mice In Vivo
    Authors: Huang, AC (Huang, An-Cheng);Lin, SY (Lin, Shuw-Yuan);Su, CC (Su, Chin-Cheng);Lin, SS (Lin, Song-Shei);Ho, CC (Ho, Chin-Chin);Hsia, TC (Hsia, Te-Chun);Chiu, TH (Chiu, Tsan-Hung);Yu, CS (Yu, Chun-Shu);Ip, SW (Ip, Siu-Wan);Lin, TP (Lin, Tsung-Ping);Chung, JG (Chung, Jing-Gung)
    Contributors: Department of Biotechnology
    Keywords: Curcumin;DHPN (N-bis(2-hydroxypropyl)nitrosamine;tumorigenesis BALB/c mice;in vivo;DIETARY CURCUMIN;CANCER CELLS;COLON CARCINOGENESIS;CLINICAL-TRIAL;TUMOR-CELLS;APOPTOSIS;RATS;CHEMOPREVENTION;FORESTOMACH;ACTIVATION
    Date: 2008-11
    Issue Date: 2010-03-26 10:29:38 (UTC+8)
    Publisher: Asia University
    Abstract: Curcumin (diferuloylmethane), a phenolic compound front the plant Curcuma longa (Linn.) has been shown to exhibit antitumor activity and apoptosis in many human cancer cell lines including that of lung and liver cancer. In this study, curcumin was evaluated in BALB/c mice for its ability to inhibit pulmonary and liver adenoma formation and growth after they were orally treated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). Animals were treated with DHPN in water for approximately 14 days before multiple doses of curcumin were given intraperitoneally. It was found that 200 mu M curcumin reduced lung and liver tumor multiplicity by 37% (p<0.05) and 30% (p<0.05) respectively. The results indicated that curcumin significantly inhibited pulmonary and liver adenoma formation and growth in BALB/c mice. The precise mechanism by which curcumin inhibits lung and liver tumorigenesis remains to be elucidated. Thus, curcumin appears to be a promising new chemotherapeutic and preventive agent for lung and liver cancer induced by DHPN.
    Relation: IN VIVO 22 (6): 781-785
    Appears in Collections:[生物科技學系] 期刊論文

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