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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8361


    Title: Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients
    Authors: Lin, YJ (Lin, Y-J);Chen, RH (Chen, R-H);Wan, L (Wan, L.);Sheu, JJC (Sheu, J. J-C);Huang, CM (Huang, C-M);Lin, CW (Lin, C-W);Chen, SY (Chen, S-Y);Lai, CH (Lai, C-H);Lan, YC (Lan, Y-C);Hsueh, KC (Hsueh, K-C);Tsai, CH (Tsai, C-H);Lin, TH (Lin, T-H);Huang, YM (Huang, Y-M);Chao, K (Chao, K.);Chen, DY (Chen, D-Y);Tsai, FJ (Tsai, F-J)
    Contributors: Department of Biotechnology
    Keywords: single nucleotide polymorphism;systemic lupus erythematosus;tumour necrosis factor-alpha;TUMOR-NECROSIS-FACTOR;RHEUMATOID-ARTHRITIS;HAPLOTYPE RECONSTRUCTION;PROMOTER POLYMORPHISMS;MULTIPLE-SCLEROSIS;DISEASE-ACTIVITY;SUSCEPTIBILITY;SLE;POPULATION;REGION
    Date: 2009-10
    Issue Date: 2010-03-26 10:30:05 (UTC+8)
    Publisher: Asia University
    Abstract: Tumour necrosis factor-alpha (TNF-alpha), an important proinflammatory cytokine, exerts a variety of physiological and pathogenic effects that lead to tissue destruction. Studies on the association of TNF-alpha genetic polymorphisms with systemic lupus erythematosus (SLE) have yielded inconclusive results. We investigated the association of TNF-alpha genetic polymorphisms (-1031T/C, -863C/A, -857T/C, -308A/G and +489A/G) with SLE in Taiwanese patients and controls. Our results indicate that 1) the frequency of the A-allele at -863 position was significantly higher in SLE patients (odds ratio = 1.46; 95% CI = 1.02-2.08); 2) the frequency of the A-allele at +489 position was significantly higher in SLE patients (odds ratio = 1.79; 95% CI = 1.21-2.65); 3) the AA or GA genotype frequencies at +489 position were significantly increased in SLE patients (AA genotype: odds ratio = 11.20; 95% CI = 1.36-92.55; GA genotype: odds ratio = 1.63; 95% CI = 1.03-2.58); 4) no significant association of TNF-alpha haplotypic distributions was observed, except for the haplotypes TCCGA, CACGA and CCCGG; and 5) the genotype frequency of the polymorphisms at -1031 was significantly different in patients with antinuclear antibodies (P = 0.022). The allele and genotype frequencies of the polymorphisms at -863 were not significantly different. The genotype frequency of the polymorphisms at -857 was significantly different in patients with haematological disorder (P = 0.025). The frequency of A allele of the polymorphisms at -308 was significantly increased in patients with malar rash (P = 0.033), discoid rash (P = 0.023), photosensitivity (P = 0.037), oral ulcers (P = 0.002) and serositis (P = 0.029). The genotype frequency of the polymorphisms at +489 was significantly different in patients with discoid rash and photosensitivity (data not shown; discoid rash, P = 0.031; photosensitivity, P = 0.044). These results suggest that TNF-alpha genetic polymorphisms contribute to SLE susceptibility in the Taiwanese population. Lupus (2009) 18, 974-979.
    Relation: LUPUS, 18 (11): 974-979
    Appears in Collections:[生物科技學系] 期刊論文

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