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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8362


    Title: Association of Interleukin-10 A-592C Polymorphism in Taiwanese Children with Kawasaki Disease
    Authors: Hsueh, KC (Hsueh, Kai-Chung);Lin, YJ (Lin, Ying-Ju);Chang, JS (Chang, Jeng-Sheng);Wan, L (Wan, Lei);Tsai, YH (Tsai, Yu-Hsin);Tsai, CH (Tsai, Chang-Hai);Chen, CP (Chen, Chih-Ping);Tsai, FJ (Tsai, Fuu-Jen)
    Contributors: Department of Biotechnology
    Keywords: Mucocutaneous Lymph Node Syndrome;Polymorphism;Interleukin-10;TUMOR-NECROSIS-FACTOR;PROMOTER POLYMORPHISM;CYTOKINE PRODUCTION;INTERFERON-GAMMA;IL-10;GENE;CELL;EXPRESSION;RECEPTOR;ALPHA
    Date: 2009-06
    Issue Date: 2010-03-26 10:30:05 (UTC+8)
    Publisher: Asia University
    Abstract: Abstract: Elevated serum levels of interleukin-10 (IL-10) have been reported in patients with Kawasaki disease (KD). IL-10 reduces the inflammatory actions of macrophages and T cells and it may play a significant role in the regulation of inflammatory vascular damage associated with systemic vasculitis. The aim of this study was to examine whether -592 IL-10 promoter polymorphism is a susceptibility or severity marker of KID in Chinese patients in Taiwan. The study included 105 KD patients and 100 normal controls. Genotype and allelic frequencies for the IL-10 gene polymorphism in both groups were compared. There were no significant between-group differences in the genotype distribution of IL-10 A-592C gene polymorphism (P=0.08). However, the frequency of the -592*A allele was significantly increased in the patients with KD compared with controls (71.9% vs. 61.0%, P=0.019). The odds ratio for developing KD in individuals with IL-10 -592*A allele was 1.64 (95% confidence interval, 1.06-2.52) compared to individuals with the IL-10-592*C allele. No significant difference was observed in the genotype and allelic frequencies for the IL-10 A-592C polymorphism between patients with and without coronary artery lesions. The IL-10-592*A allele may be involved in the development of KD in Taiwanese children.
    Relation: JOURNAL OF KOREAN MEDICAL SCIENCE, 24 (3): 438-442
    Appears in Collections:[生物科技學系] 期刊論文

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