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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8366


    Title: Association of interieukin-18 gene polymorphism with asthma in Chinese patients
    Authors: Lee, CC (Lee, Cheng-Chun);Lin, WY (Lin, Wei-Yong);Wan, L (Wan, Lei);Tsai, Y (Tsai, Yuhsin);Tsai, CH (Tsai, Chang-Hal);Huang, CM (Huang, Chung-Ming);Chen, CP (Chen, Chih-Ping);Tsai, FJ (Tsai, Fuu-Jen)
    Contributors: Department of Biotechnology
    Keywords: asthma;interleukin-18 (IL-18);single nucleotide polymorphisms (SNPs);SERUM IGE LEVELS;IFN-GAMMA;ATOPIC-DERMATITIS;ALLERGIC-ASTHMA;T-CELLS;IL-18;INTERLEUKIN-18;DISEASE;CYTOKINE;EOSINOPHILIA
    Date: 2008
    Issue Date: 2010-03-26 10:30:07 (UTC+8)
    Publisher: Asia University
    Abstract: Like other allergic diseases, asthma results from multiple conditions. Asthmatic beginning and severity are mediated by both environmental and genetic factors. In asthma studies, important work is realization of the genetic background and identification of genetic factors resulting in asthma development and phenomena. Here, we investigated whether interleukin (IL)-18 single nucleotide polymorphisms (SNPs) are involved in Chinese asthma patients. IL-18 (IL-18) SNP was detected by polymerase chain reaction (PCR)-based restriction analysis in 201 patients with asthma and 60 normal controls. Significant differences were found in the genotype distribution of IL-18 SNIP between asthma patients and controls (P = 0.000003). Allelic frequency of the IL-18 gene distinguished asthma patients from controls (P = 0.000066). The results revealed a significant difference between asthma patients and normal controls in IL-18 SNP and a statistical correlation between IL-18 polymorphisms (105A/C) and asthma formation. We concluded that Chinese who carry the C/C homozygote of the IL-18-105A/C gene polymorphism in coding regions may have a higher risk of developing asthma.
    Relation: JOURNAL OF CLINICAL LABORATORY ANALYSIS, 22 (1): 39-44
    Appears in Collections:[生物科技學系] 期刊論文

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