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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8387

    Title: Effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption
    Authors: Lin, WT;Lin, Wan-Teng;Huang, CC;Huang, Chi-Chang;Lin, TJ;Lin, Tien-Jen;Chen, JR;Chen, Jiun-Rong;Shieh, MJ;Shieh, Ming-Jer;Peng, HC;Peng, Hsiang-Chi;Yang, SC;Yang, Suh-Ching;Huang, CY;Huang, Chih-Yang
    Contributors: 保健系
    Keywords: alcoholic liver disease;antioxidant capacity;beta-carotene;lipid peroxidation;oxidative stress;ALPHA-TOCOPHEROL;LIVER-DISEASE;LIPID-PEROXIDATION;OXIDATIVE STRESS;ASCORBIC-ACID;IN-VIVO;ETHANOL;ENZYMES;DIET
    Date: 2009-08
    Issue Date: 2010-03-26 10:46:19 (UTC+8)
    Publisher: Asia University
    Abstract: This study examined the effects of beta-carotene on antioxidant status in rats with chronic alcohol consumption. At the beginning of experiment (week 0), according to both the plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, rats (n = 24) were divided into 3 groups and fed with a standard diet (group C), a diet containing ethanol (group E), or a diet containing ethanol and beta-carotene (group E+B). After 10 weeks, plasma AST and ALT, fat accumulation in the liver, antioxidant enzyme activities in erythrocytes and the liver, malondialdehyde (MDA), and alpha-tocopherol and retinol in plasma and hepatic samples were analyzed. The chronic alcohol diet significantly increased AST and ALT levels in plasma, and these changes were prevented by supplementing the diet with beta-carotene. Glutathione (GSH) in erythrocytes and in the liver was significantly elevated in rats fed with a diet containing beta-carotene. The results indicate that beta-carotene supplementation can prevent ethanol-induced liver damage and increase GSH concentrations in erythrocytes and the liver. Copyright (C) 2009 John Wiley & Sons, Ltd.
    Relation: CELL BIOCHEMISTRY AND FUNCTION, 27(6):344-350.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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