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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8395


    Title: Dietary Caffeic Acid, Ferulic Acid and Coumaric Acid Supplements on Cholesterol Metabolism and Antioxidant Activity in Rats
    Authors: Yeh, YH (Yeh, Yen-Hung);Lee, YT (Lee, Ya-Ting);Hsieh, HS (Hsieh, Hung-Seng);Hwang, DF (Hwang, Deng-Fwu)
    Contributors: 保健系
    Keywords: caffeic acid;ferulic acid;coumaric acid;HMG-CoA reductase;ACAT;fecal sterols;antioxidant enzymes;MICROSOMAL GLUTATHIONE TRANSFERASE;HMG-COA REDUCTASE;HIGH-FAT DIET;SUPEROXIDE-DISMUTASE;LIPID-PEROXIDATION;ACYL-COA;OXIDIZED CHOLESTEROL;HYDROGEN-PEROXIDE;TANNIC-ACID;POLYPHENOLS
    Date: 2009-04
    Issue Date: 2010-03-26 10:46:23 (UTC+8)
    Publisher: Asia University
    Abstract: This study was designed to test the lipid-lowering and antioxidative activities of three phenolic compounds, caffeic acid, ferulic acid and coumaric acid. Four groups of rats were given a semisynthetic diet containing 3% of cholesterol for 6 weeks. The control group only received a high cholesterol diet, whereas the other three groups received a diet including 0.2% of caffeic acid, 0.2% of ferulic acid and 0.2% of coumaric acid. The caffeic acid, ferulic acid and coumaric acid significantly lowered the plasma lipid and hepatic cholesterol levels compared to those in the control (p < 0.05). The hepatic HMG-CoA reductase activity was significantly lower in the caffeic acid group than in the ferulic acid and coumaric acid groups (p < 0.05), while the hepatic ACAT activity was significantly lower in the caffeic acid, ferulic acid and coumaric acid groups compared to the control group (p < 0.05). The overall potential of the antioxidant system was significantly enhanced by the caffeic acid, ferulic acid and coumaric acid supplements as the plasma and hepatic TBARS levels were lowered while the hepatic SOD activities and GSH concentration were elevated in the high-cholesterol-fed rats (p < 0.05). Furthermore, these results indicated that the supplementation of caffeic acid, ferulic acid and coumaric acid boosted the antioxidant activity in rats and promoted the excretion of neutral sterol and acidic sterol (p < 0.05), thereby leading to a decreased absorption of dietary cholesterol as well as lower plasma, hepatic cholesterol and promoted excretion of fecal sterols.
    Relation: JOURNAL OF FOOD AND DRUG ANALYSIS 17 (2): 123-132
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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