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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8397


    Title: ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells
    Authors: Cheng, YC;Cheng, Yi-Chang;Kuo, WW;Kuo, Wei-Wen;Wu, HC;Wu, Hsi-Chin;Lai, TY;Lai, Tung-Yuan;Wu, CH;Wu, Chun-Hsien;Hwang, JM;Hwang, Jin-Ming);Wang, WH;Wang, Wen-Hong;Tsai, FJ;Tsai, Fuu-Jen;Yang, JJ;Yang, Jaw-Ji;Huang, CY;Huang, Chih-Yang;Chu, CH;Chu, Chun-Hsien
    Contributors: 保健系
    Keywords: ZAK (mixed lineage protein kinase,Leucine-zipper, and sterile-alpha motif kinase);MMP-2/9;TIMP-1/2 and cardiac fibrosis;N-TERMINAL KINASE;MYOCARDIAL-INFARCTION;HEART-FAILURE;MATRIX METALLOPROTEINASES;CARDIAC MYOCYTES;HYPERTROPHIC GROWTH;INHIBITION;P38;PATHWAYS;PROTEIN
    Date: 2009-05
    Issue Date: 2010-03-26 10:46:24 (UTC+8)
    Publisher: Asia University
    Abstract: Leucine-zipper and sterile-alpha motif kinase (ZAK) is the key intra-cellular mediator protein in cardiomyocyte hypertrophy induction by transforming growth factor beta 1 (TGF-beta 1) which has also been identified as a profibrotic cytokine involved in cardiac fibrosis progression. We hypothesized whether ZAK over-expression causes cardiac scar formation due to the extra-cellular matrix (ECM) degraded enzyme regulation in this paper. Using immuno-histochemical analysis of the human cardiovascular tissue array, we found a positively significant association between ZAK over-expression and myocardial scars. ZAK over-expression in H9c2 cardiomyoblast cells increases the metalloproteinase tissue inhibitor 1/2 (TIMP-1/2) protein level, which reduces matria metalloproteinase-9 (MMP-9) activity and also activates c-JNK N-terminal kinase 1/2 (JNK1/2) and p38 signaling, which induces MMP-2, possibly resulting in cardiac fibrosis. Taken together, ZAK activity inhibition may be a good strategy to prevent the cardiac fibrosis progression.
    Relation: MOLECULAR AND CELLULAR BIOCHEMISTRY, 325(1-2):69-77.
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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