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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8430


    Title: Beneficial effects of treatment with cystamine on brain in NZB/W F1 mice
    Authors: Hsu, TC (Hsu, Tsai-Ching);Chen, YC (Chen, Yi-Chen);Lai, WX (Lai, Wen-Xian);Chiang, SY (Chiang, Szu-Yi);Huang, CY (Huang, Chih-Yang);Tzang, BS (Tzang, Bor-Show)
    Contributors: 保健系
    Keywords: NP-SLE (neuropsychiatric SLE);MMP-9 (matrix metalloproteinase-9);uPA (urokinase-type plasminogen activator);apoptosis;NF-kappa B;SYSTEMIC-LUPUS-ERYTHEMATOSUS;CENTRAL-NERVOUS-SYSTEM;TRANSGLUTAMINASE INHIBITOR CYSTAMINE;FACTOR-KAPPA-B;HEAT-SHOCK PROTEINS;NEUROPSYCHIATRIC MANIFESTATIONS;DISEASE;MATRIX-METALLOPROTEINASE-9;EXPRESSION;AUTOANTIBODIES
    Date: 2008-09
    Issue Date: 2010-03-26 10:46:39 (UTC+8)
    Publisher: Asia University
    Abstract: The involvement of the central nervous system (CNS) or neuropsychosis has been reported in patients with systemic lupus erythematosus (SLE) and considered a major cause of long-standing functional impairment and mortality. However, little is known in the improvement of the brain abnormality in SLE.To investigate the effect and mechanism of cystamine on brain in SLE, NZB/W F1 mice were used as the animal model. Gel zymography, caspase-3 activity assay and Western blots were performed to elucidate the effect of cystamine. Significant reduction of matrix metalloproteinases (MMP)-9/MMP-2 ratio and urokinase-type plasminogen activator (uPA) expression was detected in brain of NZB/W F1 mice treated with cystamine as compared to control group. Significant increase of heat-shock protein (HSP)-70 and HSP27 was detected in brain of NZB/W F1 mice treated with cystamine as compared to control group. Additionally, significant reduction of mitochondrial dependent apoptosis was observed in brain of NZB/W F1 mice treated with cystamine as compared to control group by increasing BCL-2 and reducing caspase-9, Bad, and Apaf-1 expression. Moreover, increased phosphorylated p65 (NF-kappa B) protein was observed in brain of NZB/W F1 mice treated with cystamine as compared to control group. These experimental results firstly demonstrated the beneficial effects of cystamine on brain in NZB/W F1 mice and suggested the therapeutic potential in patients with neuropsychiatric SLE (NP-SLE). (c) 2008 Elsevier B.V. All rights reserved.
    Relation: EUROPEAN JOURNAL OF PHARMACOLOGY 591 (1-3): 307-314
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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