ASIA unversity:Item 310904400/8432
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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8432


    Title: Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet
    Authors: Hsu, TC;Hsu, Tsai-Ching;Chiang, SY;Chiang, Szu-Yi;Wu, JH;Wu, Jen-Huang;Tsai, CC;Tsai, Chun-Chou;Huang, CY;Huang, Chih-Yang;Chen, YC;Chen, Yi-Chen;Tzang, BS;Tzang, Bor-Show
    Contributors: 保健系
    Keywords: Apoptosis;cholesterol;liver;systemic lupus erythematosus (SLE);taurine;SYSTEMIC-LUPUS-ERYTHEMATOSUS;TRANSGLUTAMINASE INHIBITOR CYSTAMINE;ACID-INDUCED APOPTOSIS;OXIDATIVE STRESS;CYCLOSPORINE-A;RAT-LIVER;ACTIVATION;CELLS;INFLAMMATION;MECHANISM
    Date: 2008-10
    Issue Date: 2010-03-26 10:46:40 (UTC+8)
    Publisher: Asia University
    Abstract: Cholesterol-rich diets are known to cause hepatic apoptosis, which has been associated with the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanisms and treatments for hepatic apoptosis in SLE are poorly understood. To clarify the effects of taurine on hepatic apoptosis in SLE, NZB/W F1 mice received control, cholesterol, and cholesterol/taurine diets. Significant reductions of caspase-3 activity, TUNEL-positive cells, and Fas- and mitochondrial- dependent apoptosis were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. Moreover, significant increases of phosphorylated AKT, NF-kappa B (p65), and ERK1/2 proteins were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. In contrast, a significant reduction of phosphorylated p38 protein was observed in the cholesterol/taurine group. These experimental results demonstrated positive effects of taurine against hepatic apoptosis in NZB/W F1 mice fed a high-cholesterol diet and suggested the therapeutic potential of taurine in SLE.
    Relation: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56(20):9685-9691.
    Appears in Collections:[Department of Food Nutrition and Healthy Biotechnology] Journal Article

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