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    题名: The Proliferation and Migration Effects of Huangqi on RSC96 Schwann Cells
    作者: Fang, WK (Fang, Wen-Kuei);Ko, FY (Ko, Fu-Yang);Wang, HL (Wang, Hwai Lee);Kuo, CH (Kuo, Chia-Hua);Chen, LM (Chen, Li-Mien);Tsai, FJ (Tsai, Fuu-Jen);Tsai, CH (Tsai, Chang-Hai);Chen, YS (Chen, Yueh-Sheng);Kuo, WW (Kuo, Wei-Wen);Huang, CY (Huang, Chih-Yang)
    贡献者: Department of Healthcare Administration
    关键词: Huangqi;Proliferative Effect;Schwann Cells;Sciatic Nerve;Peripheral Nerve Regeneration
    日期: 2009
    上传时间: 2010-03-26 10:52:34 (UTC+8)
    出版者: Asia University
    摘要: This study evaluated the proliferation effects of huangqi on neuron regeneration. We investigated the molecular mechanisms, which include: (1) cyclin D1, A, E-cell cycle factors and MAPK signaling proliferation (2) FGF-2-UPA-MMPs migration signaling. After treatment with various Huanqi concentrations (1.25, 12.5, 125, 250 and 500 mu g/ml,), we observed that Huanqi can increase Rsc 96 cell proliferation at 12.5 mu g/ml (p < 0.01) concentration determined by the MTT and wound healing tests. Examination by RT-PCR and Western blotting assay showed that Huangqi is able to stimulate the mRNA and protein expressions of cyclin D1, A, E, cell cycle controlling proteins and excite ERK and P38 MAPK signaling pathways to promote cell proliferation. Huangqi stimulates the FGF-2-UPA-MMP9 migration pathway and enhances RSC 96 Schwann cells migration. Using MAPK chemical inhibitors, U0126, SB203580 and SP600125, the proliferative effects of Huangqi oil RSC 96 cells were ERK and P38 signaling-dependent. Based oil these results, applying an appropriate dose of Huangqi with biomedical materials would be a potential approach to enhancing neuron regeneration.
    显示于类别:[健康產業管理學系] 期刊論文


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