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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8470

    Title: Proliferative Effects of Chishao on Schwann Cells are FGF-uPA, and ERK- and JNK-Dependent
    Authors: Huang, KS (Huang, Kun Shan);Lu, MJ (Lu, Min-Jin);Chen, YS (Chen, Yueh-Sheng);Tsai, FJ (Tsai, Fuu-Jen);Kuo, WW (Kuo, Wei-Wen);Cheng, YC (Cheng, Yi-Chang);Lin, CC (Lin, Chien-Chung);Tsai, CH (Tsai, Chang-Hai);Huang, CY (Huang, Chih-Yang);Lin, JG (Lin, Jaung-Geng);Ou, HC (Ou, Hsiu-Chung)
    Contributors: Department of Healthcare Administration
    Keywords: Chishao;Proliferative Effect;Schwann Cells;Nerve Regeneration
    Date: 2009
    Issue Date: 2010-03-26 10:52:34 (UTC+8)
    Publisher: Asia University
    Abstract: This study evaluated the proliferative effects of chishao on RSC96, Schwann cells. A dose-dependent proliferative effect of chishao was obtained by methylthiazol tetrazolium( MTT), proliferating cell nuclear antigen (PCNA) Western blotting, and wound healing assays in Schwann cells administered with chishao (0-500 mg/ml), except at 500 mg/ml concentration. The chishao-treated cells also showed a dose-dependent activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA) and decreased plasminogen activator inhibitor-1 (PAI-1), enhanced proliferative proteins, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-signaling. Using mitogen-actvated protein kinase (MAPK)-signaling chemical inhibitors, U0126, SB203580, and SP600125, the proliferative effects of chishao on RSC cells were identified to be ERK- and JNK- signaling dependent. Based on the results, applying appropriate doses of chishao to Schwann cells would be a potential approach for enhancing neuron regeneration.
    Relation: AMERICAN JOURNAL OF CHINESE MEDICINE 37 (6): 1191-1202
    Appears in Collections:[健康產業管理學系] 期刊論文

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