ASIA unversity:Item 310904400/8477
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    题名: Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice
    作者: Hsu, TC (Hsu, Tsai-Ching);Huang, CY (Huang, Chih-Yang);Chiang, SY (Chiang, Szu-Yi);Lai, WX (Lai, Wen-Xian);Tsai, CH (Tsai, Chang-Hai);Tzang, BS (Tzang, Bor-Show)
    贡献者: Department of Healthcare Administration
    关键词: systematic lupus erythematosus (SLE);liver;cystamine;NZB/W F1 mice;SYSTEMIC-LUPUS-ERYTHEMATOSUS;SELECTIVE CYCLOOXYGENASE-2 INHIBITORS;C-REACTIVE PROTEIN;APOPTOTIC CELLS;NK CELLS;MICE;SLE;P53;INFLAMMATION;DISEASES
    日期: 2008-01
    上传时间: 2010-03-26 10:52:37 (UTC+8)
    出版者: Asia University
    摘要: Increased hepatic abnormality has been observed in patients with systemic lupus erythematosus (SLE) and contributes to the elevated apoptosis that results in severe disease activity. Since cystamine has been demonstrated to be beneficial for NZB/NV F1 mice, this study investigates the effects of cystamine on various inflammatory and stress-related proteins in liver from NZB/W F I mice. Nephelometric analyses and immunoblots were conducted to detect aspartate aminotransferase (AST), alanine aminotransferase (ALT), C-reactive protein (CRP), p53, p21, Gadd45, heat shock protein 70 (HSP70) and cyclooxygenase-2 (COX-2). AST and ALT were reduced in NZB/W F1 mice that were given cystamine and CRP, p53, p21, Gadd45, HSP70 and COX-2 proteins in the liver were reduced in NZB/W F1 mice that were treated with cystamine. Moreover, cystamine has no obvious effect on BALB/c mice. These findings suggest that cystamine reduces the inflammation in liver of NZB/W F1 mice and provide a clue in treatment of SLE with liver abnormality. (c) 2007 Elsevier B.V. All rights reserved.
    關聯: EUROPEAN JOURNAL OF PHARMACOLOGY 579 (1-3): 382-389
    显示于类别:[健康產業管理學系] 期刊論文

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