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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/8502


    Title: Significant association of XRCC4 single nucleotide polymorphisms with prostate cancer susceptibility in Taiwanese males
    Authors: Chang, CH (Chang, Chao-Hsiang);Chiu, CF (Chiu, Chang-Fang);Wu, HC (Wu, Hsi-Chin);Tseng, HC (Tseng, Hsien-Chang);Wang, CH (Wang, Chung-Hsing);Lin, CC (Lin, Cheng-Chieh);Tsai, CW (Tsai, Chia-Wen);Liang, SY (Liang, Shiu-Yun);Wang, CL (Wang, Cheng-Li);Bau, DT (Bau, Da-Tian)
    Contributors: Department of Healthcare Administration
    Keywords: XRCC4;single nucleotide polymorphism;prostate;DNA repair;BREAST-CANCER;P53;EPIDEMIOLOGY;RISK
    Date: 2008-07
    Issue Date: 2010-03-26 10:52:49 (UTC+8)
    Publisher: Asia University
    Abstract: The DNA repair gene X-ray cross-complementing group 4 (XRCC4), a member of the non-homologous end-joining (NHEJ) repair system, plays a major role in the repair of the double-strand breaks of the DNA sequence. This gene is critical to the maintenance of overall genome stability, and is also thought to play a key role in human carcinogenesis. In this case-control study, several novel polymorphic variants of XRCC4, including C-1622T (rs7727691), G-1394T (rs6869366), C-571T (rs2075686) and intron3 DIP (rs28360071), were investigated, and the correlation of these variants to prostate cancer susceptibility in a Taiwanese population was observed. A total of 134 prostate cancer patients were recruited along with 134 age-matched healthy controls, and the association of their selected genotypes with susceptibility to prostate cancer was determined. The G-1394T variant of XRCC4 proved, after analysis of the frequencies of each variant in the prostate cancer and control groups, to be a significant single nucleotide polymorphism (SNP) in prostate carcinogenesis. Our data clearly indicate that the heterogeneous G of G-1394T increases the risk of suceptibility to prostate cancer (P=0.0106), while no difference in distribution of XRCC4 C-1622T (rs7727691), C-571T (rs2075686) or intron3 DIP (rs28360071) between the prostate cancer and control groups was found. In conclusion, our findings suggest that the G allele of XRCC4 G-1394T may be responsible for prostate carcinogenesis, and could be useful in the early detection and prevention of the disease.
    Relation: MOLECULAR MEDICINE REPORTS 1 (4): 525-530
    Appears in Collections:[健康產業管理學系] 期刊論文

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